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Updated: Jan 16, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Renal AA Amyloidosis
1Division of Kidney Diseases and Hypertension, Alpert Medical School of Brown University, Providence, RI.
Abstract:
Amyloidosis is a rare systemic condition caused by extracellular deposition of misfolded fibrillary protein aggregates leading to progressive organ dysfunction. The kidney is a common site of amyloid deposition, with variable clinical presentations. Here, we will review pathophysiology, clinical manifestation, diagnosis and management of renal AA amyloidosis. Although significant progress has been made in understanding the disease pathophysiology and improving diagnostic yield, the treatment options remain limited, and the overall prognosis depends on the control of underlying inflammation.
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