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Updated: Jan 16, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
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Curcumin Inhibits Protease Activated Receptor 2-Induced ERK Phosphorylation Calcium Mobilization and Anti-Apoptotic

Rajashree Patnaik1, Riah Varghese1, Ahad Al-Kabani1

  • 1College of Medicine and Health Sciences, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Health, Dubai 505055, United Arab Emirates.

Cells
|September 26, 2025
PubMed
Summary

Curcumin effectively targets the PAR-2 signaling pathway, downregulating key inflammatory and anti-apoptotic markers in colorectal cancer (CRC) cells. This study validates curcumin as a potential therapeutic agent for inflammation-driven CRC.

Keywords:
Caspase-8ERK phosphorylationGPCR modulationPAR-2 signalingTNF-αapoptosiscalcium mobilizationcolorectal cancercurcuminmolecular docking

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