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Updated: Jan 16, 2026
04:58
Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds
Published on: October 20, 2012
12.4K
Inflammation-Responsive Hydrogels in Perioperative Pain and Wound Management: Design Strategies and Emerging
Young Eun Moon1, Jin-Oh Jeong2, Hoon Choi1
1Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Gels (Basel, Switzerland)
|September 26, 2025
Summary
Inflammation-responsive hydrogels offer precise, localized drug delivery for surgical wounds, adapting to the body's signals to reduce pain and improve healing. These smart biomaterials promise better postoperative care by targeting inflammation effectively.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Surgical Innovation
Background:
- Surgical inflammation impacts pain, healing, and outcomes.
- Systemic drug delivery lacks precision and causes side effects.
- Inflammation-responsive hydrogels offer localized, adaptive drug release.
Purpose of the Study:
- Review perioperative inflammation pathophysiology.
- Outline design principles of responsive hydrogels.
- Evaluate payload integration and translational relevance.
Main Methods:
- Narrative review of inflammation-responsive hydrogel systems.
- Analysis of pH-, reactive oxygen species-, and enzyme-sensitive platforms.
- Evaluation of integrated payloads (NSAIDs, corticosteroids, biologics).
Main Results:
- Preclinical studies show efficacy in various surgical models.
- Hydrogels modulate immune responses, reduce pain, and enhance regeneration.
- Demonstrated therapeutic synergy and translational relevance of integrated payloads.
Conclusions:
- Responsive hydrogels enable precise perioperative care.
- Challenges include trigger fidelity and surgical compatibility.
- Future advances may accelerate clinical translation via biosensors and AI.
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