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Click Chemistry-Based Hydrogels for Tissue Engineering.

Soheil Sojdeh1, Amirhosein Panjipour1, Amal Yaghmour1

  • 1Department of Ophthalmology and Visual Science, University of Illinois, Chicago, IL 60612, USA.

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|September 26, 2025
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Summary
This summary is machine-generated.

Click chemistry enables advanced hydrogel design for tissue engineering, offering precise control and enhanced bioactivity. Challenges like reagent cost and copper toxicity are being addressed for broader clinical use.

Keywords:
click chemistrycrosslinked hydrogeltissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Click chemistry offers high specificity, rapid kinetics, and biocompatibility for hydrogel fabrication.
  • Key click reactions include azide-alkyne cycloadditions, thiol-ene/yne, Diels-Alder, and tetrazine-norbornene couplings.

Purpose of the Study:

  • To review the principles and applications of click chemistry in designing advanced hydrogels for tissue engineering.
  • To explore strategies for enhancing hydrogel bioactivity and control over biological cues.
  • To discuss current challenges and future directions in click chemistry-based biomaterials.

Main Methods:

  • Review of click chemistry principles (efficiency, orthogonality, modularity).
  • Analysis of common click reactions for hydrogel formation.
  • Exploration of bioactivity enhancement strategies and control mechanisms.
  • Discussion of tissue engineering applications and 3D bioprinting.

Main Results:

  • Click chemistry facilitates the creation of injectable, responsive, biodegradable, and multifunctional hydrogels.
  • Incorporation of peptides, growth factors, and ECM components enhances hydrogel bioactivity.
  • Promising applications demonstrated in cartilage, skin, neural, and cardiovascular tissue regeneration.

Conclusions:

  • Click chemistry provides versatile tools for creating sophisticated hydrogels for diverse tissue engineering applications.
  • Addressing challenges like copper toxicity and scalability is crucial for clinical translation.
  • Future directions include advanced biofabrication integration and in vivo applications.