Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

471
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
471
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

795
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
795
Hypertension I: Introduction01:28

Hypertension I: Introduction

743
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
743
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

882
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
882
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

540
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
540

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammation, Autonomic Control, and Adiposity in Adolescents: Links to Early Cardiovascular Risk.

Life (Basel, Switzerland)·2025
Same author

Effect of Submaximal Doses of Semaglutide in Patients with Obesity on Metabolic Profile and Serum Levels of Adipocytokines.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Extracellular Vesicles Derived from Breast Cancer Cells: Emerging Biomarkers of Tumor Progression and Metastasis.

Biomolecules·2025
Same author

Effects of Ketamine vs. Midazolam in Adolescent Treatment Resistant Depression.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Complexity of electrodermal activity to mental stress is changed during adolescent age-period.

General physiology and biophysics·2024
Same author

Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Jan 16, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.4K

Endothelial Dysfunction in Adolescent Hypertension: Diagnostic Challenges and Early Cardiovascular Risk.

Vladimir Micieta1, Michaela Cehakova2, Ingrid Tonhajzerova1

  • 1Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.

Journal of Cardiovascular Development and Disease
|September 26, 2025
PubMed
Summary

Hypertension in adolescents leads to early vascular injury and endothelial dysfunction (ED), increasing cardiovascular risk. Early detection and interventions like exercise, diet, and medication can reverse ED and preserve vascular health in youth.

Keywords:
adolescent hypertensioncardiovascular riskendothelial dysfunctionimagingmasked hypertensionnitric oxideoxidative stresspubertywhite-coat hypertension

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

18.6K

Related Experiment Videos

Last Updated: Jan 16, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.4K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

18.6K

Area of Science:

  • Cardiovascular Research
  • Pediatric Health
  • Vascular Biology

Background:

  • Adolescent hypertension is linked to early vascular damage, specifically endothelial dysfunction (ED).
  • Endothelial dysfunction signifies heightened cardiovascular risk in young individuals.
  • Pubertal hormonal shifts exacerbate vascular changes.

Purpose of the Study:

  • To review recent findings (2020-2025) on the mechanisms and detection of ED in hypertensive adolescents.
  • To explore the reversibility of ED and its implications for cardiovascular risk management.
  • To emphasize the importance of early ED identification in youth.

Main Methods:

  • Synthesis of recent scientific literature (2020-2025) on endothelial dysfunction in hypertensive youth.
  • Analysis of non-invasive diagnostic tools for ED assessment (e.g., flow-mediated dilation, peripheral arterial tonometry).
  • Review of intervention strategies including lifestyle modifications and pharmacotherapy.

Main Results:

  • Reduced nitric oxide bioavailability, oxidative stress, inflammation, and hormonal changes contribute to ED and vascular remodeling.
  • Asymptomatic hypertensive adolescents exhibit measurable ED, arterial stiffness, and cardiac changes.
  • Endothelial dysfunction in youth is reversible through interventions.

Conclusions:

  • Early identification of ED in hypertensive adolescents is crucial for accurate risk stratification.
  • Interventions such as exercise, diet, and medications (ACE inhibitors, ARBs) can improve endothelial function.
  • Prompt management of ED in youth offers a window to preserve long-term vascular health and prevent cardiovascular disease.