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Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
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Efficient Retinal Vessel Segmentation with 78K Parameters
Zhigao Zeng1, Jiakai Liu1, Xianming Huang1
1School of Computer Science, Hunan University of Technology, Zhuzhou 412007, China.
Journal of Imaging
|September 26, 2025
Summary
DSAE-Net offers accurate retinal vessel segmentation for diabetic retinopathy diagnosis using a lightweight dual-stage network. This efficient model reduces complexity while improving performance, aiding real-time clinical applications.
Area of Science:
- Medical Imaging
- Deep Learning
- Ophthalmology
Background:
- Diabetic retinopathy diagnosis relies on retinal vessel segmentation.
- Current deep learning models often face accuracy-complexity trade-offs.
- Efficient segmentation is crucial for clinical settings.
Purpose of the Study:
- To develop a lightweight yet accurate deep learning model for retinal vessel segmentation.
- To address the limitations of existing models in terms of computational complexity and accuracy.
- To facilitate early diagnosis of diabetic retinopathy.
Main Methods:
- Proposed DSAE-Net, a dual-stage network featuring a Parameterized Cascaded W-shaped Architecture.
- Introduced Skeleton Distance Loss (SDL) to manage class imbalance and boundary issues.
- Developed Cross-modal Fusion Attention (CMFA) and Coordinate Attention Gates (CAGs) for enhanced feature refinement.
- Utilized DRIVE, CHASE_DB1, HRF, and STARE datasets for evaluation.
Main Results:
- DSAE-Net achieved superior segmentation accuracy compared to state-of-the-art lightweight models.
- The proposed architecture significantly reduced computational complexity (using only 1% of U-Net parameters).
- The model demonstrated robustness across multiple benchmark datasets.
- SDL effectively handled severe class imbalance inherent in retinal images.
Conclusions:
- DSAE-Net provides an efficient and accurate solution for retinal vessel segmentation.
- The model's low complexity and high performance are suitable for real-time diagnostics.
- This approach supports early detection of diabetic retinopathy in resource-limited environments.

