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Published on: September 16, 2013
Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an Okeania sp. Marine Cyanobacterium
Sein Higa1, Kazumasa Yagisawa1, Noriyuki Natsume2
1Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
Abstract:
Two linear lipopeptides mabuniamide B (1) and C (2) were isolated from an Okeania sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of 1 and 2. In addition, 1 and 2 inhibited uric acid production in cultured AML12 cells.
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