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Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells
Published on: December 2, 2010
Macromolecular Crowding for Reparative Medicine and Drug Discovery Applications
Giulia Giuffredi1, Andrea Rossoni1, Laura Trujillo Cubillo1
1Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Charles Institute of Dermatology, Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering, University College Dublin (UCD), Dublin, Ireland.
Abstract:
Cell-based reparative medicine and drug discovery utilise the innate sophistication of cells to build supramolecular assemblies. Unfortunately, bereft of their optimal tissue context, during in vitro culture, this ability is compromised. Herein, we argue that macromolecular crowding is the missing link in the development of tissue facsimiles for reparative medicine and drug discovery purposes.
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