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Published on: April 19, 2015
Freeze-dried and imprinted collagen scaffolds in tendon engineering
Ignacio Sallent1, Lefki Chaniotaki2, Dimitrios I Zeugolis3
1Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) and CÚRAM Research Ireland Centre for Medical Devices, University of Galway, Galway, Ireland.
None:
Collagen type I, as the main component of tendons, is an attractive biomaterial for the development of scaffolds for tendon repair and regeneration. Herein, we review advancements in freeze-drying and soft lithography scaffold fabrication procedures that permit the manufacturing of collagen scaffolds with precise architectural features. We also provide an overview of collagen crosslinking strategies that allow for the development of scaffolds with appropriate stiffness and cytocompatibility. In addition, we appraise the contribution of freeze-dried and imprinted collagen scaffolds in tendon engineering.
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