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ECM-Lamin Crosstalk in the Regulation of Genomic Stability
Bipasa Mandal1,2, Indrakshi Banerjee1,2, Md Wasim Akram Ddoza Hazari1,2
1Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, West Bengal, India.
Sub-Cellular Biochemistry
|September 26, 2025
Summary
The extracellular matrix (ECM) and nuclear lamina interact to control gene expression and genome stability. Disruptions in this interplay can lead to diseases like cancer.
Area of Science:
- Cell Biology
- Epigenetics
- Biophysics
Background:
- The extracellular matrix (ECM) and nuclear lamina are crucial for cellular structure and function.
- Their dynamic interplay influences mechanotransduction and gene regulation.
- Understanding this interaction is key to comprehending cellular processes.
Purpose of the Study:
- To explore the intricate relationship between the ECM and nuclear lamina.
- To elucidate how ECM variations affect nuclear architecture and gene expression.
- To highlight the role of ECM-lamin dynamics in disease pathogenesis.
Main Methods:
- Investigated the impact of ECM stiffness and composition on nuclear morphology.
- Analyzed changes in lamin protein expression and localization.
- Examined resulting epigenetic modifications and chromatin organization.
Main Results:
- ECM variations significantly alter nuclear architecture and lamin A/C levels.
- These changes modulate histone modifications, DNA methylation, and chromatin compaction.
- Dysfunctional ECM-lamin interactions are linked to aberrant gene expression and genomic instability.
Conclusions:
- The ECM-lamin axis is a critical regulator of epigenetic programming and genome maintenance.
- Disruptions in this axis contribute to disease progression, especially cancer.
- Targeting ECM-lamin dynamics may offer novel therapeutic avenues for mechanotransduction-related diseases.
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