Rapid and sensitive detection of dextran sulfate based on an ionic liquid-based turn-on micro-optode

Area of Science:

• Analytical Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Dextran sulfate sodium salt (DSS) is a crucial biomacromolecule with diverse applications.
• Accurate and sensitive detection methods for DSS are essential for various fields.
• Existing detection techniques can be costly and complex.

Purpose of the Study:

• To develop a novel fluorometric method for sensitive dextran sulfate sodium salt (DSS) detection.
• To create a cost-effective and user-friendly paper-based test kit for DSS.
• To explore the potential of ionic liquid-based photonic materials in optode fabrication.

Main Methods:

• Development of a fluorescent micro-optode using a next-generation fluorescent ionic liquid (mHPTIL).
• Fluorometric detection of DSS in aqueous media.
• Design and testing of a paper-based test kit for visual DSS detection.

Main Results:

• The mHPTIL micro-optode demonstrated high sensitivity for DSS detection, with limits in the ng mL⁻¹ range.
• The developed method showed selectivity over other biomacromolecules.
• A functional paper-based test kit was successfully created for rapid and visual DSS identification.

Conclusions:

• The novel fluorometric method provides a sensitive and rapid approach for DSS detection.
• The paper-based test kit offers a low-cost, instrument-free alternative for DSS analysis.
• Ionic liquid-based photonic materials show promise for developing advanced photoluminescent optodes for diverse applications.