Hirsutane sesquiterpenoids from basidiomycete Pseudohydropus cf. parafunebris
Somporn Palasarn1, Malipan Sappan1, Kitlada Srichomthong1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand.
Abstract:
Two undescribed hirsutane-type sesquiterpenes, hydropusins A (1) and B (2), along with two known hirsutanes, 6,7-epoxy-4(15)-hirsutene-5-ol (3) and 6,7-epoxy-4(15)-hirsutene-1,5-diol (4), were isolated from the basidiomycete Pseudohydropus cf. parafunebris TBRC-BCC 55386, cultivated in the presence of the epigenetic regulator nicotinamide. The absolute configuration of compound 1 was determined using the modified Mosher method. Compounds 1 and 3 showed weak cytotoxicity towards NCI-H187 cancer cells, with IC50 values of 161 and 144 µM, respectively.
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Fungal Phylum Basidiomycota
Fungal Group Zygomycota


