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Prenylhydroquinone-derived metabolites from cultures of basidiomycete Panus similis
Somporn Palasarn1, Siriporn Saepua1, Seangaroon Yoiprommarat1
1National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klong Luang, Pathumthani 12120, Thailand.
Abstract:
Two undescribed prenylhydroquinone-derived metabolites, panusidones A (1) and B (2), were isolated from cultures of basidiomycete Panus similis TBRC-BCC 52578, together with the structurally related known compounds panepoxydone (3) and panepoxydione (4). The structure was elucidated by extensive NMR spectroscopic analyses and mass spectrometry data. Panusidone A (1) showed weak antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 50 µg/ml). It was devoid of cytotoxicity to NCI-187 and MCF-7 human tumor cell-lines, while the known major co-metabolites, panepoxydone and panepoxydione, showed significant proliferation inhibitions.
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