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Association between multi inflammatory index and heart failure in patients with coronary heart disease: a RCSCD-TCM
Yuanyuan He1, Tong Yang1, Yuting Li1
1Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Insights
The multi-inflammatory index (MII) is associated with heart failure (HF) risk in coronary heart disease (CHD) patients. MII-1 demonstrated the strongest association, particularly in women and those with hypertension or diabetes.
Area of Science:
- Cardiology
- Inflammation Research
- Public Health
Background:
- Anti-inflammatory therapy presents a potential therapeutic target for heart failure (HF).
- The multi-inflammatory index (MII), a composite measure of inflammation, requires further investigation regarding its association with HF.
- The precise relationship between MII and HF in coronary heart disease (CHD) patients remains unclear.
Purpose of the Study:
- To investigate the association between the multi-inflammatory index (MII) and the risk of heart failure (HF).
- To examine this association specifically within a cohort of patients diagnosed with coronary heart disease (CHD).
Main Methods:
- A cohort study involving 17,937 CHD patients, with 6,386 diagnosed with HF.
- Logistic regression analysis was employed to assess the relationship between MII and HF.
- Subgroup analyses were conducted based on sex, blood pressure, and blood glucose levels.
Main Results:
- MII-1 showed the highest odds ratio (OR: 1.33) for HF compared to other MII tertiles.
- The association between MII-1 and HF was stronger in females than males.
- MII-1 was significantly associated with increased HF risk in CHD patients with hypertension (OR: 1.06) and diabetes (OR: 1.04).
Conclusions:
- The multi-inflammatory index (MII) is significantly associated with heart failure (HF) risk in coronary heart disease (CHD) patients.
- The association between MII and HF risk was more pronounced in women.
- MII-1 emerged as a superior indicator of HF risk in this patient population.
Background:
Anti-inflammatory therapy could become a new target for the treatment of heart failure (HF), and multi inflammatory index (MII) is a new index composed of an inflammatory index. Then, the relationship between MII and HF is not completely clear.
Objectives:
The aim of this study was to investigate the association of MII and HF in coronary heart disease (CHD) patients.
Methods:
In a cohort of 17,937 patients with CHD, 6386 had HF. Logistic regression analysis was used to analyze the relationship between the MII and HF in CHD patients. The relationship between MII and HF was also assessed according to sex, blood pressure, and blood glucose.
Results:
Compared with T1 of MII, MII-1 had the highest T3 (OR: 1.33; 95% CI: 1.23-1.45; P < 0.001), and MII-3 had the lowest T3 (OR: 1.25; 95% CI: 1.16-1.36; P < 0.001). In both sexes, MII-1 was more associated with HF than MII-2 and MII-3. In binary logistic regression analysis, when MII was treated as a continuous variable, MII-1 was significantly associated with HF risk in CHD patients with hypertension (OR: 1.06; 95% CI: 1.02-1.10; P = 0.002) and in CHD patients with diabetes (OR: 1.04; 95% CI: 1.00-1.08; P = 0.040). All MII were associated with HF. The MII-1 proved to be superior.
Conclusion:
In patients with CHD, the association between the MII and HF was stronger in female than in male. There was a association between MII and risk of HF in with CHD patients after multivariate adjustment.
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