Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peripheral macrophages and T-cells accumulate in the degenerating optic tract after repetitive head impact.

Brain, behavior, and immunity·2026

Same author

<i>Grin2b</i> 3'UTR is necessary for synaptic plasticity and spatial learning.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

High frequency head impact exposure changes hippocampal sharp-wave ripple architecture.

PloS one·2026

Same author

Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms.

PLoS biology·2025

Same author

Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model.

Tissue engineering and regenerative medicine·2025

Same author

Non-invasive therapeutics for neurotrauma: a mechanistic overview.

Frontiers in neurology·2025

Same journal

Ocular speech tracking persists in blindness, but its dynamics and oculo-cerebral connectivity depend on visual status.

eNeuro·2026

Same journal

Emergent multidien cycles from partial circadian synchrony.

eNeuro·2026

Same journal

Adolescent social isolation induces persistent impairments in emotional discrimination and helping behavior.

eNeuro·2026

Same journal

Increased Ih Current Is Associated with Reduced Hippocampal CA1 Excitability in a Mouse Model of Multiple Sclerosis.

eNeuro·2026

Same journal

Reduced SuM Activation Accompanies Impaired Social Novelty Recognition in Mouse Models of Neurodevelopmental Disorders.

eNeuro·2026

Same journal

Do Not Forget the Stimulus: A Missing Control in Naturalistic Studies of Neural Entrainment.

eNeuro·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Low-Cost 3D-Printed Mazes with Open-Source ML Tracking for Mouse Behavior.

James D O'Leary¹, Dhwani C Gondalia¹, Molly O'Brien¹

¹Laboratory for Brain Injury and Dementia, Department of Neuroscience, Georgetown University Medical Centre, Washington, DC 20057.

|September 26, 2025

Summary

This summary is machine-generated.

This study combines 3D printing and machine learning to create affordable behavioral neuroscience research tools. This innovative approach reduces costs for custom mouse mazes and automated behavior analysis, enhancing accessibility for scientists.

Keywords:

3D printing behavior learning and memory machine learning open source

More Related Videos

Low-stress Route Learning Using the Lashley III Maze in Mice

Low-stress Route Learning Using the Lashley III Maze in Mice

Published on: May 22, 2010

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jan 16, 2026

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Low-stress Route Learning Using the Lashley III Maze in Mice

Low-stress Route Learning Using the Lashley III Maze in Mice

Published on: May 22, 2010

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Area of Science:

Behavioral Neuroscience
Computational Neuroscience
Biomedical Engineering

Background:

High costs of specialized equipment and software pose significant barriers in behavioral neuroscience research.
Limited funding restricts access to essential tools for early-career scientists and established laboratories.
Need for cost-effective and customizable solutions to advance research in cognition and anxiety-like behaviors.

Purpose of the Study:

To investigate the integration of 3D printing and machine learning for cost reduction in behavioral neuroscience.
To develop and validate affordable, custom-designed mouse behavioral assessment tools.
To implement machine learning for accurate and automated behavioral analysis.

Main Methods:

3D printing was utilized to fabricate custom mouse T-mazes and elevated plus mazes.
Machine learning algorithms were integrated for automated tracking and behavioral analysis of male mice.
The efficacy and accuracy of custom-built mazes and analysis software were compared to commercial alternatives.

Main Results:

3D-printed mazes demonstrated comparable efficacy to commercial options, offering enhanced affordability and customization.
Machine learning-based behavioral analysis achieved accuracy on par with commercial solutions and human scoring.
The combined approach significantly reduced both startup and operational costs for behavioral research.

Conclusions:

The integration of 3D printing and machine learning offers a cost-effective solution for behavioral neuroscience research.
This approach lowers financial barriers for new investigators and optimizes resource allocation for established labs.
The developed methodology expands research capabilities and promotes greater accessibility in the field.