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Updated: May 17, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

High frequency head impact exposure changes hippocampal sharp-wave ripple architecture.

Daniel P Chapman^1,2, Margaret S Sten^1,2, Stefano Vicini^2,3

¹Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America.

|January 9, 2026

Summary

This summary is machine-generated.

High-frequency head impacts (HFHI) in mice impair cognitive function by altering hippocampal sharp-wave ripples (SWR). These changes reduce SWR amplitude and power, suggesting a novel neural biomarker for head impact injuries.

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Last Updated: May 17, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

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Published on: November 19, 2012

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

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Published on: August 28, 2020

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Area of Science:

Neuroscience
Sports Medicine
Cognitive Science

Background:

Repeated head impacts in sports cause cognitive deficits without apparent brain pathology.
High-frequency head impact (HFHI) in mice alters synaptic function and impairs cognition.
The effect of HFHI on intrinsic neural plasticity and potential biomarkers remains unclear.

Purpose of the Study:

To investigate how HFHI affects hippocampal sharp-wave ripples (SWR).
To determine if SWR can serve as a neural biomarker for HFHI.
To characterize changes in SWR architecture following HFHI.

Main Methods:

Acute hippocampal slices were prepared from HFHI and sham mice 24 hours post-impact.
Field recordings were used to characterize spontaneous sharp-wave ripples (SWR).
SWR amplitude, power, ripple cycle count, and ripple power were quantified.

Main Results:

Physiological SWR were present in both HFHI and sham groups, with grossly intact architecture.
HFHI mice exhibited significantly decreased SWR amplitude and power compared to sham controls.
Reduced number of ripple cycles per event and diminished ripple power were observed in HFHI brains.

Conclusions:

HFHI alters hippocampal SWR architecture, specifically reducing SWR amplitude and power.
These SWR alterations may contribute to the cognitive impairments observed in the HFHI mouse model.
SWR changes represent a potential neural biomarker for detecting the effects of HFHI.