Unraveling the Bone-Brain Communication Network.
Surajit Hansda1, Hiranmoy Das1
1Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, ARB Suite 2116, 1406 South Coulter Street, Amarillo, TX 79106, USA.
Biology
|September 27, 2025
Summary
The bone and brain communicate bidirectionally through molecular signals, influencing each other
Area of Science:
- Bone and neurobiology
- Endocrinology
- Molecular biology
Background:
- Bone and brain exhibit shared physical, molecular, and developmental traits.
- Bidirectional communication (crosstalk) exists between bone and brain systems.
- This crosstalk is mediated by hormones, cytokines, extracellular vesicles (EVs), and neural signals.
Purpose of the Study:
- To review the molecular basis of bone-brain crosstalk.
- To highlight the roles of inflammation, aging, and regulatory pathways.
- To discuss future directions in biomarker discovery and therapeutic targeting.
Main Methods:
- Literature review of existing studies on bone-brain communication.
- Analysis of molecular signaling pathways and transcriptional regulators.
- Examination of shared biomarkers and pathological links.
Main Results:
- Bone-derived factors (e.g., osteocalcin) affect cognitive functions and neurogenesis.
- Brain-derived factors (e.g., leptin) influence bone remodeling.
- Inflammation and aging disrupt bone-brain communication, impacting cognitive and bone health.
Conclusions:
- Bone-brain crosstalk is crucial for maintaining homeostasis.
- Disruptions in this axis contribute to age-related disorders like cognitive decline and osteoporosis.
- Understanding this communication offers opportunities for early diagnosis and dual-targeted therapies.
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