Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Language of Pathophysiology l01:25

Introduction to Language of Pathophysiology l

213
Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like...
213
Introduction to Language of Pathophysiology ll01:17

Introduction to Language of Pathophysiology ll

48
This lesson explores key terms that describe how diseases progress, their outcomes, and their distribution in populations.Diagnostic tests identify diseases and monitor treatment. These include blood and urine tests, biopsies, imaging (X-ray, MRI), and detection of infectious agents.Remission is a reduction or disappearance of symptoms.Exacerbation refers to the worsening of symptoms, such as increased wheezing during an asthma attack.A precipitating factor triggers an acute episode, while a...
48

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Temperature and the Duration of Freezing on a Hydrogel Used for a 3D-Bioprinted In Vitro Skin Model.

Biomedicines·2024
Same author

Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief.

Materials (Basel, Switzerland)·2023
Same author

Apremilast Use in Severe Psoriasis: Real-World Data from Central and Eastern Europe.

Advances in therapy·2023
Same author

Novel Methacrylate-Based Multilayer Nanofilms with Incorporated FePt-Based Nanoparticles and the Anticancer Drug 5-Fluorouracil for Skin Cancer Treatment.

Pharmaceutics·2022
Same author

Artificial Biomimetic Electrochemical Assemblies.

Biosensors·2022
Same author

Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties.

Pharmaceutics·2021

Related Experiment Video

Updated: May 4, 2026

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

741

Exploring Genital Lichen Sclerosus: Navigating from Pathophysiology to Precise Diagnostic Approaches.

Maja Sever1, Katarina Trčko2, Tanja Zidarič3

  • 1Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.

Biomedicines
|September 27, 2025
PubMed
Summary

Lichen sclerosus (LS) is a chronic skin condition impacting quality of life. This review clarifies LS pathophysiology, focusing on autoimmune issues, tissue scarring, and oxidative stress for better treatment strategies.

Keywords:
autoimmune dysregulationgenital diseaselichen sclerosusoxidative stresssclerotic tissue

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

858
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

568

Related Experiment Videos

Last Updated: May 4, 2026

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

741
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

858
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

568

Area of Science:

  • Dermatology
  • Immunology
  • Pathophysiology

Background:

  • Lichen sclerosus (LS) is a chronic, relapsing inflammatory skin disease.
  • LS predominantly affects genital/perineal areas, impacting sexual and urinary function.
  • LS is often underdiagnosed despite its significant impact on quality of life.

Purpose of the Study:

  • To clarify the complex pathophysiology of Lichen sclerosus.
  • To explore the roles of autoimmune dysregulation, sclerotic tissue formation, and oxidative stress in LS.
  • To provide insights for developing targeted therapies and improving LS management.

Main Methods:

  • Review of existing literature on Lichen sclerosus pathophysiology.
  • Analysis of mechanisms including autoimmune responses, fibroblast activity, and oxidative damage.
  • Examination of key molecular mediators like miR-155 and galectin-7.

Main Results:

  • Autoimmune dysregulation involves T-cell infiltration and dysfunction of miR-155 and ECM1.
  • miR-155 and galectin-7 contribute to sclerotic tissue formation via fibroblast proliferation.
  • Oxidative stress exacerbates tissue damage, autoimmunity, and increases carcinogenesis risk.

Conclusions:

  • Understanding LS pathophysiology involves autoimmune dysregulation, fibrosis, and oxidative stress.
  • Targeted therapies require further research into LS genetic basis and immune responses.
  • Advancing precision medicine for LS necessitates unraveling mediator interactions.