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A Potential Role of Adropin in Inflammatory Rheumatic Diseases-What Do We Know So Far?
Petra Simac1, Marin Petric1, Marijana Jankovic Danolic2
1Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Hospital of Split, 21000 Split, Croatia.
Biomedicines
|September 27, 2025
Summary
Adropin, a peptide hormone, influences autoimmune rheumatic diseases (ARDs) by affecting immune cells and tissue processes. Altered adropin levels in ARDs suggest its potential as a biomarker or therapeutic target.
Area of Science:
- Endocrinology
- Immunology
- Rheumatology
Background:
- Adropin is a peptide hormone regulating metabolism, cardiovascular health, and immunity.
- Emerging evidence links adropin to the pathophysiology of autoimmune rheumatic diseases (ARDs).
Purpose of the Study:
- To review adropin's biological functions.
- To explore adropin's relevance in various ARDs.
- To discuss adropin's potential as a biomarker or therapeutic target.
Main Methods:
- Literature review of adropin's role in ARDs.
- Analysis of adropin's interaction with signaling pathways.
- Examination of adropin's influence on immune cell regulation and tissue remodeling.
Main Results:
- Adropin influences endothelial function, oxidative stress, fibrosis, and immune cell regulation in ARDs.
- Altered adropin levels are observed across multiple ARDs, including rheumatoid arthritis, lupus, and scleroderma.
- Adropin may modulate macrophage polarization, regulatory T cell activity, and fibrotic processes.
Conclusions:
- Adropin is implicated in the pathogenesis of various ARDs.
- Further research is necessary to validate adropin's role and clinical utility in immune-mediated diseases.
- Adropin presents a potential target for novel therapeutic strategies in ARDs.
Keywords:
adropinautoimmune diseasesbiomarkercardiovascular diseasesendothelial dysfunctionmetabolic homeostasisoxidative stressMore Related Videos
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