BAN Score and Distinct Early Cardiometabolic Risk Signatures in a Non-Diabetic Population: A Cross-Sectional Analysis

Area of Science:

• Cardiology
• Metabolic Health
• Biomarkers

Background:

• The BMI-albumin-neutrophil-to-lymphocyte (BAN) score combines adiposity, nutritional status, and inflammation.
• Its utility in detecting early cardiometabolic changes in non-diabetic individuals is not well-established.

Purpose of the Study:

• To investigate the association between the BAN score and vascular, glycemic, and lipid markers.
• To assess the BAN score's potential as an early indicator of cardiometabolic risk.

Main Methods:

• Retrospective cross-sectional study of 162 non-diabetic adults.
• Analysis included Spearman's correlation, ROC analysis, and adjusted regression models.
• Vascular (SBP, PP), glycemic (HbA1c), and lipid parameters were assessed.

Main Results:

• Higher BAN scores correlated with increased systolic blood pressure (SBP), pulse pressure (PP), and HbA1c.
• Adjusted models showed BAN score increases were associated with higher SBP, PP, and HbA1c.
• The BAN score demonstrated moderate discriminative ability for hypertension and elevated HbA1c.

Conclusions:

• The BAN score is associated with early cardiometabolic risk factors, including elevated SBP, widened PP, and glycemic alterations.
• Further research is needed to elucidate the BAN score's underlying mechanisms and its potential for preventive strategies.