From Obscurity to Prominence: IPMK's Expanding Role in Cellular Signaling, Physiology, and Disease
Subrata H Mishra1, Sujan Chatterjee2, Loretta Viera-Preval2,3
1Institute for Bioscience and Biotechnology Research, National Institute of Standards and Technology, University of Maryland, Rockville, MD 20850, USA.
Biomolecules
|September 27, 2025
Summary
Inositol polyphosphate multikinase (IPMK) is a key enzyme regulating cellular signals. Research reveals its crucial roles in development, disease, and as a potential therapeutic target.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Biology
Background:
- Inositol polyphosphate multikinase (IPMK) has emerged as a critical enzyme in cellular signaling.
- It possesses dual inositol and lipid kinase activities, producing key signaling molecules like InsP4, InsP5, and PIP3.
Purpose of the Study:
- To review the journey of IPMK from obscurity to prominence in cellular biology.
- To examine IPMK's structure-function relationships, cellular roles, and physiological impacts.
- To highlight IPMK's potential as a therapeutic target in human diseases.
Main Methods:
- Literature review of multidisciplinary research over two decades.
- Analysis of studies on IPMK's structure-function relationships.
- Examination of IPMK's roles in nutrient sensing, growth factor signaling, mRNA transport, and transcription.
Main Results:
- IPMK is essential for mammalian embryonic development.
- IPMK plays significant roles in nutrient sensing, growth factor signaling, mRNA transport, and transcription regulation.
- IPMK is implicated in various diseases, including neurodegeneration, cancer, and inflammation.
Conclusions:
- IPMK is a versatile enzyme with far-reaching biological roles.
- Its involvement in diverse cellular mechanisms and diseases underscores its importance.
- IPMK presents a promising therapeutic target for human health and disease management.
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