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Rehabilitation Protocols and Functional Outcomes in Oncological Patients Treated with Modular Megaprosthesis: A
Filip Fryderyk Brzeszczyński1, Michał Karpiński1, Marcel Aleksander Brzeszczyński2
1Department of Trauma, Orthopaedics and Musculoskeletal Oncology, Copernicus Memorial Hospital, 93-513 Lodz, Poland.
Cancers
|September 27, 2025
Summary
Rehabilitation after bone tumour resection with megaprostheses is complex. Early active mobilisation appears safe and may improve outcomes for patients undergoing oncologic reconstruction.
Area of Science:
- Orthopaedic Oncology
- Reconstructive Surgery
- Rehabilitation Medicine
Background:
- Bone reconstruction with megaprostheses is common after bone tumour resections, including sarcomas.
- There is limited consensus on postoperative rehabilitation protocols and outcomes for this patient group.
Purpose of the Study:
- To systematically review the literature on rehabilitation protocols and functional outcomes following bone tumour resection and megaprosthesis reconstruction.
- To identify factors influencing patient outcomes in orthopaedic oncology.
Main Methods:
- A systematic literature search was performed in MEDLINE and EMBASE databases.
- Studies were included if they described rehabilitation protocols and functional outcomes after bone tumour resection and modular oncologic megaprosthesis reconstruction.
- Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool.
Main Results:
- Thirteen studies involving 371 patients were included. Rehabilitation protocols varied, with brace immobilisation ranging from 10 days to 6 months.
- Early active exercises at 6 weeks were associated with superior shoulder scores.
- Early mobilisation showed enhanced outcomes for proximal femur prostheses, with no increased risk of dislocation.
Conclusions:
- Literature on rehabilitation and outcomes following megaprosthesis arthroplasty in orthopaedic oncology is limited and protocols are inconsistently described.
- Early active mobilisation does not appear to increase the risk of joint dislocations or infections.
- Further research is needed to establish standardized rehabilitation guidelines.
