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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Single-port robot-assisted adrenalectomy: technical considerations and a single-center experience.

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Updated: Jun 25, 2026

Retzius-Sparing Robot-Assisted Radical Prostatectomy
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Latest Advancements and Future Directions in Prostate Cancer Surgery: Reducing Invasiveness and Expanding

Valerio Santarelli1,2, Roberta Corvino1, Giulio Bevilacqua1

  • 1Department of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy.

Cancers
|September 27, 2025
PubMed
Summary

Advancements in prostate cancer (PCa) surgery include innovative techniques like Single Port (SP) robotic surgery and AI-assisted tools. New approaches such as partial prostatectomy and radioguided surgery are improving outcomes and minimizing side effects for localized and advanced PCa.

Keywords:
RARPprostate cancerprostatectomysurgery

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Area of Science:

  • Urology
  • Surgical Oncology
  • Robotic Surgery

Background:

  • Robotic-Assisted Radical Prostatectomy (RARP) has dominated prostate cancer (PCa) surgical research for over two decades.
  • Recent innovations introduce new techniques, surgical approaches, and expanded indications in PCa management.

Purpose of the Study:

  • To review emerging innovative techniques and expanded indications in prostate cancer surgery.
  • To highlight advancements beyond traditional RARP.
  • To discuss the future trajectory of PCa management.

Main Methods:

  • Review of recent literature on novel surgical techniques and technologies in prostate cancer treatment.
  • Analysis of emerging trends in robotic surgery, AI applications, and minimally invasive approaches.
  • Evaluation of new indications for surgical intervention based on disease stage and characteristics.

Main Results:

  • Single Port (SP) robotic surgery offers benefits like reduced hospital stay, improved cosmetics, and less pain.
  • Artificial Intelligence (AI) shows promise for standardizing robotic training and surgical assistance.
  • Partial prostatectomy is emerging as a minimally invasive option for localized tumors, and radioguided surgery enhances lymph node dissection for locally advanced disease.

Conclusions:

  • Emerging techniques like SP robotics, AI, partial prostatectomy, and radioguided surgery are poised to significantly influence the future of prostate cancer management.
  • These innovations aim to improve oncological outcomes while minimizing treatment-related side effects.
  • The evolving landscape of PCa treatment is shaping international guidelines and management strategies.