Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The clinical impact of amino acid positron emission tomography measurements in the treatment of primary malignant brain tumors].

Orvosi hetilap·2023
Same author

Therapy Defining at Initial Diagnosis of Primary Brain Tumor-The Role of <sup>18</sup>F-FET PET/CT and MRI.

Biomedicines·2023
Same author

PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis.

Biomedicines·2022
Same author

Determination of complex type free, non-conjugated oligosaccharide glucose unit values in tomato xylem sap for early detection of nutrient deficiency.

Electrophoresis·2020
Same author

Music and Visual Art Training Modulate Brain Activity in Older Adults.

Frontiers in neuroscience·2019
Same author

A New Suggested Strategy for Safe Injection of Ozurdex.

Ophthalmic surgery, lasers & imaging retina·2019
Same journal

RETRACTED: Sabir et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. <i>Cancers</i> 2021, <i>13</i>, 3396.

Cancers·2026
Same journal

Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

Cancers·2026
Same journal

Correction: Peñalver et al. Guidelines for Diagnosis, Treatment, and Follow-Up of Patients with Follicular Lymphoma-Spanish Lymphoma Group (GELTAMO) 2026. <i>Cancers</i> 2026, <i>18</i>, 395.

Cancers·2026
Same journal

Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

Cancers·2026
Same journal

Age-Stratified Long-Term Outcomes of Immune Checkpoint Inhibitors for Stage IV Melanoma and NSCLC in The Netherlands: A Population-Based Study.

Cancers·2026
Same journal

Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.

Cancers·2026
See all related articles

Related Experiment Video

Updated: Jan 16, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K

Brainstem Glioma Prognostication: Static FET PET/CT.

Dávid Gergő Nagy1, Júlia Singer2, Katalin Borbély3

  • 1Department of Neurosurgery and Neurointervention, Semmelweis University, 1145 Budapest, Hungary.

Cancers
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Amino acid PET/CT, using O-(2-[18F]fluoroethyl)-L-tyrosine (FET) and a tumor-to-brain ratio (TBR) of 2.9, can accurately detect high-grade brainstem glioma. This aids in identifying patients with poor prognoses for timely treatment.

Keywords:
FET PET/CTTBR cutoff valueamino acid PET/CTbrainstem glioma

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.8K

Related Experiment Videos

Last Updated: Jan 16, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.8K

Area of Science:

  • Neuro-oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Brainstem glioma classification and staging present challenges, often relying on radiological features due to limited biopsy accessibility.
  • Accurate and early identification of malignant brainstem lesions is crucial for effective treatment planning and improving patient quality of life.

Purpose of the Study:

  • To evaluate the utility of amino acid Positron Emission Tomography/Computed Tomography (PET/CT) with O-(2-[18F]fluoroethyl)-L-tyrosine (FET) for metabolic mapping in brainstem lesions.
  • To determine the optimal tumor-to-brain ratio (TBR) threshold for differentiating high-grade from low-grade brainstem gliomas.

Main Methods:

  • Retrospective analysis of 20 patients with uncertain brainstem lesions who underwent static FET PET/CT.
  • Calculation and analysis of multiple tumor-to-brain ratios (TBR) to correlate with patient survival outcomes.

Main Results:

  • A maximum Youden index was achieved at a TBR of 2.9.
  • This TBR threshold demonstrated high sensitivity (91.7%) for detecting high-grade lesions.
  • While positive (68.8%) and negative (75.0%) predictive values were good, specificity was lower (37.5%).

Conclusions:

  • Static FET PET/CT is effective in improving the detection accuracy of high-grade brainstem gliomas.
  • A TBR value of 2.9 is identified as the most suitable threshold for predicting poor prognosis in brainstem glioma patients.
  • This imaging technique aids in the critical decision-making process for initiating appropriate therapy.