Immunonutrition: Another Player on the MASLD Field.

Area of Science:

• Nutrition Science
• Hepatology
• Immunology

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing chronic liver condition.
• Inflammation and oxidative stress are central to MASLD progression.
• Immunonutrition offers a strategy to modulate these pathways via dietary nutrients.

Purpose of the Study:

• To highlight the importance of immunonutrition in MASLD management.
• To discuss the limitations of current dietary guidelines (e.g., Mediterranean Diet) for MASLD.
• To advocate for individualized and locally adapted dietary strategies.

Main Methods:

• Review of immunonutrition principles and their application to MASLD.
• Analysis of dietary patterns and their impact on liver health.
• Consideration of factors influencing dietary adherence and accessibility.

Main Results:

• The Mediterranean Diet, while rich in immunonutrients, faces accessibility challenges.
• Immunonutrition strategies can complement pharmacological treatments and physical activity.
• Dietary interventions must be tailored to individual patient characteristics and local food environments.

Conclusions:

• Individualized dietary recommendations incorporating immunonutrients are crucial for effective MASLD treatment.
• Adapting diets to local food availability enhances patient adherence and outcomes.
• Immunonutrition represents a vital component of a comprehensive MASLD management plan.