Probiotics in IBD: Evidence and Perspectives on Patient Health and Disease Management

Area of Science:

• Gastroenterology and Microbiology
• Immunology

Background:

• Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, affects individuals globally.
• IBD pathogenesis involves genetic, environmental, immune, and microbial factors, notably reduced gut microbial diversity.
• The gut microbiota influences host health through direct interactions and metabolites.

Purpose of the Study:

• To review randomized clinical trials (RCTs) assessing probiotic efficacy in IBD.
• To evaluate probiotics for IBD treatment, prevention, and remission maintenance.

Main Methods:

• Systematic review of human randomized clinical trials.
• Analysis of studies investigating various probiotic strains and formulations.
• Assessment of outcomes related to IBD activity and remission.

Main Results:

• Probiotics show potential in modulating gut microbiota composition and function.
• Evidence suggests varied efficacy of different probiotics in IBD management.
• Further research is needed to establish optimal probiotic strategies for IBD.

Conclusions:

• Probiotic application is a promising strategy for IBD management.
• Personalized probiotic approaches may be necessary for effective IBD treatment.
• RCTs provide valuable insights into the role of probiotics in IBD.