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Updated: Jun 27, 2026

Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Gut Microbiota as an Innovative Therapeutic Target in Cardiovascular Diseases from a Metabolic and Inflammatory
Emília Hijová1, Izabela Bertková1, Veronika Benetinová1
1Center of Clinical and Preclinical Research, MediPark, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, SNP 1, 040 11 Košice, Slovakia.
Abstract:
The gut microbiome plays a key role in the pathogenesis of cardiovascular disease through systemic inflammation, impaired lipid metabolism, and proatherogenic gut metabolites like trimethylamine N-oxide. Gut dysbiosis contributes to decreased level of microbial metabolites such as short-chain fatty acids, bile acids, coprostanol, and phenylacetylglutamine, as well as increased intestinal permeability and platelet hyper-reactivity, and exacerbating cardiovascular risk. New microbiome-focused treatments such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation are showing potential to help reduce cardiovascular diseases. However, bringing these therapies into clinical settings is difficult because they vary by strain and individual response. The gut-heart connection offers an innovative approach to preventing and treating heart condition, but additional research is needed to ensure lasting effectiveness and safety.
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