Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy.

International journal of molecular sciences·2026

Same author

Tricyclic Antidepressants as Prospective α-Synucleinopathy Fighters: Evidence of Protein Binding and Antiaggregation Activity.

ACS chemical neuroscience·2026

Same author

Off-Resonance Enhancement of the Refractive Index via Indirect Optical Transitions.

Nano letters·2025

Same author

Protein-Ligand Interactions: Recent Advances in Biophysics, Biochemistry, and Bioinformatics.

International journal of molecular sciences·2025

Same author

Heat generation in spatially confined solids through electronic light scattering.

Nanophotonics (Berlin, Germany)·2025

Same author

Quantum chemical properties of chlorinated polycyclic aromatic hydrocarbons for delta machine learning.

Scientific data·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Novel Organomineral Complex with Prolonged Antitumor Action.

Olga Ilinskaya¹, Galina Yakovleva¹, Pavel Zelenikhin¹

¹Microbiology Department, Institute of Fundamental Medicine and Biology of Kazan (Volga-Region) Federal University, Kazan Federal University, Kremlevskaya St., 18, Kazan 420008, Russia.

International Journal of Molecular Sciences

|September 27, 2025

Summary

Researchers developed a novel drug delivery system using binase, an antitumor enzyme, immobilized on a rock carrier for sustained release in the gastrointestinal tract. This approach enhances cancer cell targeting and offers potential for long-acting antitumor therapy.

Keywords:

antitumor activity binase cytotoxicity human adenocarcinoma cells porosity prolonged enzyme release stability zeolite

More Related Videos

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Related Experiment Videos

Last Updated: Jun 5, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Area of Science:

Biotechnology
Materials Science
Oncology

Background:

Cancer cell proliferation is often targeted by blocking the MAPK pathway.
Drug resistance and KRAS mutations limit the effectiveness of current cancer therapies.
Ribonuclease binase from Bacillus pumilus interacts with EGFR and RAS, inhibiting this pathway.

Purpose of the Study:

To design, optimize, and characterize a novel complex for prolonged release of antitumor binase.
To immobilize binase on microgranular clinoptilolite-containing rock for sustained gastrointestinal release.
To evaluate the antitumor and detoxifying properties of the developed complex.

Main Methods:

Characterization of clinoptilolite carrier using electron microscopy (TEM, SEM) and computed tomography.
Measurement of binase particle size via atomic force microscopy.
Assessment of binase stability and activity using calorimetry and model gastrointestinal fluids.

Main Results:

The carrier's granularity, porosity, and elemental composition were analyzed.
Binase particles (7 nm) effectively penetrated the carrier's pores.
Binase demonstrated stability at high temperatures and retained activity in simulated GI fluids.
The complex exhibited gradual enzyme release over 20 hours, showing cytotoxicity against adenocarcinoma cells.

Conclusions:

A novel long-acting complex of antitumor binase immobilized on clinoptilolite was successfully created.
The complex demonstrates sustained release and potent cytotoxicity against cancer cells.
This system offers a promising approach for long-acting antitumor and detoxifying therapy.