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Related Experiment Videos

Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy.

Olga Ilinskaya¹, Konstantin Vagin², William Kurdy¹

¹Department of Microbiology, Kazan (Volga-Region) Federal University, Kremlevskaya St., 18, Kazan 420008, Russia.

International Journal of Molecular Sciences

|June 12, 2026

Summary

A novel biomineral complex effectively restores the gut microbiome disrupted by radiotherapy in mice. This treatment also reduces radiation-induced chromosomal damage, offering a promising approach for managing radiotherapy side effects.

Keywords:

Lactobacillaceae alpha and beta diversity chromosomal aberrations clinoptilolite-containing carrier functional analysis microbiome radiotherapy side effects

Related Experiment Videos

Area of Science:

Microbiology
Radiotherapy Research
Gastroenterology

Background:

Radiotherapy is a crucial cancer treatment, but often causes gut dysbiosis.
Current probiotic treatments face challenges with inactivation in the gastrointestinal tract.
A novel biomineral complex offers a potential solution for microbiome restoration.

Purpose of the Study:

To evaluate the efficacy of a novel biomineral complex in restoring the intestinal microbiome of irradiated mice.
To assess the impact of the biomineral complex on radiation-induced side effects, specifically clastogenesis.
To confirm the safety and microbiome-restoring potential of the clinoptilolite-lactobacilli complex.

Main Methods:

16S rRNA gene sequencing for fecal metagenome analysis.
Assessment of alpha-diversity and microbial dynamics in irradiated mice.
Nuclear Magnetic Resonance (NMR) analysis of the mineral carrier and evaluation of chromosomal aberrations.

Main Results:

The biomineral complex demonstrated a significant microbiome-restoring effect in mice exposed to radiation.
Administration of the complex reduced the level of radiation-induced chromosomal aberrations.
NMR analysis confirmed the safety of the mineral carrier component.

Conclusions:

The novel biomineral complex is effective in restoring the gut microbiome after radiation exposure.
This complex mitigates radiation-induced clastogenesis, suggesting therapeutic potential.
The findings support the use of this biomineral complex for managing radiotherapy complications.