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Association Study of SPARCL1 Gene Polymorphisms in Ischemic Stroke

Seong Shin Kwak1,2, Ki Ook Lee3, Chang Soo Ryu1,2

  • 1Department of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.

Genes
|September 27, 2025
PubMed

Insights

Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) gene variations are linked to ischemic stroke risk. These SPARCL1 polymorphisms may serve as potential biomarkers for predicting stroke and guiding brain injury treatment strategies.

Area of Science:

  • Genetics and Genomics
  • Neurology
  • Biomarker Discovery

Background:

  • Stroke, a cerebrovascular disorder, causes significant brain damage and physical impairment.
  • The hevin-calcyon protein interaction is implicated in brain injury repair.
  • Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) encodes the hevin protein.

Purpose of the Study:

  • To investigate the association between SPARCL1 gene polymorphisms and ischemic stroke.
  • To identify potential genetic biomarkers for ischemic stroke risk assessment and treatment.

Main Methods:

  • A case-control study involving 509 ischemic stroke patients and 387 controls.
  • Genotyping of SPARCL1 polymorphisms (rs1049544, rs1130643, rs7695558, rs1049539) using real-time polymerase chain reaction (PCR) and TaqMan™ SNP Genotyping Kit.

Main Results:

  • The rs1049544 polymorphism showed a significant association with ischemic stroke prevalence.
  • rs1049544 was linked to large-artery disease, and rs1130643 was associated with cardioembolism.
  • Haplotype analysis revealed associations of G-G (rs1049544/rs7695558) and C-T (rs1049544/rs1049539) with ischemic stroke prevalence.

Conclusions:

  • SPARCL1 gene polymorphisms are significantly associated with ischemic stroke.
  • These findings suggest SPARCL1 polymorphisms as potential biomarkers for ischemic stroke risk assessment.
Abstract

Keywords:
SPARCL1hevin–calcyon bindingischemic strokepolymorphism

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