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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

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Related Experiment Video

Updated: Jan 16, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Molecular Screening for Cervical Cancer.

Toni Ricardo Martins^1,2, José Eduardo Levi³

¹Programa de Pós Graduação em Imunologia Básica e Aplicada-PPGIBA, Universidade Federal do Amazonas, Manaus 14040-903, Brazil.

|September 27, 2025

Summary

This summary is machine-generated.

Human Papillomavirus (HPV) DNA testing is replacing the Pap test for cervical cancer screening due to its high sensitivity. This shift necessitates new strategies for managing increased screening-positive cases.

Keywords:

cervical cancer human papillomavirus screening

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Area of Science:

Oncology
Molecular Diagnostics
Public Health

Background:

Cervical cancer (CC) is a prevalent neoplasia in women.
Cervicovaginal cytology (Pap test) has been the standard screening method.
Human Papillomaviruses (HPVs) are definitively linked to cervical cancer etiology.

Purpose of the Study:

To review current cervical cancer screening strategies.
To contextualize molecular assays in cervical cancer detection.
To evaluate the transition from Pap tests to HPV testing.

Main Methods:

Discussion of molecular screening tools.
Analysis of advantages and disadvantages of various molecular markers.
Review of current HPV testing protocols.

Main Results:

Oncogenic HPV DNA testing is the primary molecular screening strategy, supplanting cervicovaginal cytology.
HPV DNA is the most sensitive marker for detecting cervical cancer and precursor lesions.
Increased screening-positive individuals due to HPV testing create demand for triage resources.

Conclusions:

HPV DNA testing offers superior sensitivity for cervical cancer detection.
The rise in HPV testing necessitates advanced triage and risk-based management strategies.
Ongoing development of new algorithms and technologies aims to optimize screening outcomes.