Non-Ossifying Fibromas: A 2025 Review

Area of Science:

• Pediatric Orthopedics
• Skeletal Radiology
• Pediatric Pathology

Background:

• Non-ossifying fibromas (NOFs) are common, benign bone lesions in pediatric populations.
• These self-limiting lesions constitute a significant portion of skeletal abnormalities in children and adolescents.

Purpose of the Study:

• To provide a comprehensive review of incidentally found bone lesions in children and adolescents, focusing on NOFs.
• To integrate historical perspectives with current diagnostic and management strategies for NOFs.
• To assist clinicians in optimizing diagnostic and treatment protocols for NOFs.

Main Methods:

• Literature review encompassing historical descriptions, epidemiological data, histopathology, and advanced imaging findings of NOFs.
• Analysis of diagnostic criteria and current management strategies for NOFs.
• Exploration of emerging molecular insights related to NOFs.

Main Results:

• NOFs are benign, self-limiting lesions with a well-documented history and characteristic features.
• Key epidemiologic, histopathologic, and advanced imaging findings are outlined.
• Current diagnostic criteria and management options are discussed, alongside novel molecular discoveries.

Conclusions:

• A thorough understanding of NOFs is crucial for accurate diagnosis and effective management in pediatric patients.
• This review aims to reduce unnecessary interventions by providing clinicians with comprehensive knowledge of NOFs.
• Integrating historical context with modern insights enhances clinical decision-making for NOFs.