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Mesoporous Silica Nanoparticles as Drug Delivery Systems.

Flórián Benkő1, Katalin Kristó1, Tamás Sovány1

  • 1Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u 6, H-6720 Szeged, Hungary.

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Summary

Mesoporous silica nanocarriers (MSNs) enhance drug delivery by stabilizing active pharmaceutical ingredients (APIs) in an amorphous state. This improves solubility, protects drugs from degradation, and enables targeted delivery for better therapeutic outcomes.

Keywords:
drug deliveryfunctionalizationmesoporous silicananoparticlesstimuli-responsivetoxicity

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Mesoporous silica nanocarriers (MSNs) are advanced materials for drug delivery.
  • Their porous structure offers unique advantages for encapsulating active pharmaceutical ingredients (APIs).

Purpose of the Study:

  • To review recent findings on MSNs for therapeutic and drug formulation applications.
  • To highlight the role of MSN characteristics in drug delivery and targeted therapy.

Main Methods:

  • Review of literature on MSNs in drug delivery.
  • Analysis of MSN properties such as pore size, surface chemistry, and particle size.
  • Examination of functionalization strategies for targeted delivery.

Main Results:

  • MSNs improve API aqueous solubility and stability by forming an amorphous state.
  • Encapsulation within MSNs protects drugs from degradation, enhancing bioavailability.
  • MSN functionalization allows for organ-, tissue-, or cell-specific targeted delivery.
  • Particle size and surface properties influence cell membrane interactions, epithelial permeability, and drug release rates.

Conclusions:

  • MSNs represent a promising platform for developing advanced drug delivery systems.
  • Their tunable properties facilitate enhanced drug solubility, stability, and targeted delivery.
  • MSNs offer potential for improved therapeutic efficacy and reduced drug-related side effects.