Promising Norlabdane-Heterocyclic Hybrids: Synthesis, Structural Characterization and Antimicrobial Activity...

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Natural Products Chemistry

Background:

• Terpeno-heterocyclic molecular hybrids offer a promising class of compounds due to their biological activity, natural origins, and biocompatibility.
• Norlabdane derivatives, sourced from waste biomass of Clary sage, serve as a sustainable starting material.

Purpose of the Study:

• To synthesize and evaluate novel norlabdane-heterocyclic hybrids for their biological activities.
• To explore efficient and environmentally friendly synthetic methodologies for these hybrids.

Main Methods:

• Synthesis via coupling reactions of norlabdane derivatives with heterocyclic compounds.
• Synthesis via heterocyclization reactions of norlabdane intermediates.
• Biological evaluation against various fungal and bacterial strains.

Main Results:

• Successful synthesis of diverse norlabdane-heterocyclic hybrids, including diazine, triazole, carbazole, oxadiazole, thiadiazole, thiazole, benzothiazole, and benzimidazole derivatives.
• Many synthesized compounds demonstrated significant antifungal and antibacterial activity.
• The use of waste biomass from Clary sage (Salvia sclarea L.) proved to be an economically and ecologically viable approach.

Conclusions:

• The synthesized norlabdane-heterocyclic hybrids show potential for the development of new therapeutic agents against fungal and bacterial infections.
• The study underscores the value of utilizing plant-based waste materials in chemical synthesis for sustainable practices.