Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

585
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
585
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

1.2K
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
1.2K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

600
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
600
Oral Hypoglycemic Agents: Sulfonylureas01:17

Oral Hypoglycemic Agents: Sulfonylureas

781
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
781

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antidiabetic Activity of Silver Nanoparticles Biosynthesized with <i>Stenocereus queretaroensis</i> Flower Extract.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Effect of Solvent and Grain Color on the Biological Activities of Maize Grain.

Foods (Basel, Switzerland)·2025
Same author

Agave-Laurate-Bioconjugated Fructans Decrease Hyperinsulinemia and Insulin Resistance, Whilst Increasing IL-10 in Rats with Metabolic Syndrome Induced by a High-Fat Diet.

Pharmaceuticals (Basel, Switzerland)·2024
Same author

Antibacterial and Antibiofilm Activity of Chemically and Biologically Synthesized Silver Nanoparticles.

Antibiotics (Basel, Switzerland)·2023
Same author

Effect of Agave Fructan Bioconjugates on Metabolic Syndrome Parameters in a Murine Model.

Pharmaceuticals (Basel, Switzerland)·2023
Same author

Toxicological Evaluation of Silver Nanoparticles Synthesized with Peel Extract of <i>Stenocereus queretaroensis</i>.

Materials (Basel, Switzerland)·2022

Related Experiment Video

Updated: Jan 16, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
07:48

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

8.0K

Biosynthesized Silver Nanoparticles and Their Antidiabetic Potential.

Angélica Sofía González-Garibay1, Omar Ricardo Torres-González1, Iván Moisés Sánchez-Hernández1

  • 1Medical and Pharmaceutical Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. (CIATEJ). Av. Normalistas No. 800 Col. Colinas de la Normal, Guadalajara C.P. 44270, Jalisco, Mexico.

Pharmaceuticals (Basel, Switzerland)
|September 27, 2025
PubMed
Summary

Biosynthesized silver nanoparticles (AgNPs) show significant potential for managing diabetes mellitus by influencing key metabolic pathways. Ongoing research highlights their promise as a novel therapeutic approach for blood glucose regulation.

Keywords:
diabetesgreen synthesishypoglycemicmetallic nanoparticles

More Related Videos

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.8K
Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.7K

Related Experiment Videos

Last Updated: Jan 16, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
07:48

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

8.0K
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.8K
Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.7K

Area of Science:

  • Nanotechnology and Materials Science
  • Biochemistry and Molecular Biology
  • Pharmacology and Therapeutics

Background:

  • Diabetes mellitus is a metabolic disorder with persistent management challenges.
  • Biosynthesized silver nanoparticles (AgNPs) are emerging as a novel therapeutic avenue.
  • AgNPs demonstrate potential effects on glucose homeostasis-related enzymes and signaling pathways.

Purpose of the Study:

  • To review the current research on the antidiabetic activity of biosynthesized AgNPs.
  • To analyze in vitro and in vivo studies evaluating AgNPs for diabetes management.
  • To present recent findings and future perspectives on AgNPs in diabetes treatment.

Main Methods:

  • Narrative review of studies identified via PubMed search using "antidiabetic + activity + AgNPs".
  • Focus on biosynthesized AgNPs from plant sources.
  • Analysis of experimental approaches, plant sources, nanoparticle characteristics, concentrations, and outcomes.

Main Results:

  • Green synthesis of AgNPs using plant bioactive compounds is an eco-friendly method.
  • Plant extracts are the primary biomaterials for AgNP biosynthesis.
  • In vitro studies often assess α-glucosidase/α-amylase inhibition; in vivo studies focus on blood glucose levels.

Conclusions:

  • The antidiabetic potential of AgNPs is increasingly supported by scientific evidence.
  • AgNPs offer a promising area for novel diabetes management strategies.
  • Further research is needed to fully elucidate and harness the therapeutic benefits of AgNPs.