Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hair Cells01:22

Hair Cells

44.4K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
44.4K
Unrenewable Cells00:50

Unrenewable Cells

2.9K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.9K
The Cochlea01:13

The Cochlea

50.5K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
50.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-Step Ensemble Convolutional Neural Networks for Colonoscopic Biopsy Classification Resembling Pathologists' Process.

Journal of Korean medical science·2026
Same author

Post-pandemic structural shifts in perinatal characteristics and outcomes.

Journal of perinatal medicine·2026
Same author

Closing the Gap in Pre-Exposure Prophylaxis Access for Sexual and Gender Minorities in South Korea: Implications for HIV Prevention Policy.

AIDS patient care and STDs·2026
Same author

Age-Related Differences in Chronic Rhinosinusitis: Inflammatory Profiles and Surgical Outcomes in Geriatric and Non-Geriatric Patients.

Clinical and experimental otorhinolaryngology·2026
Same author

A-stream glaucoma shunt versus trabeculectomy: 1-year results on efficacy and safety.

Scientific reports·2026
Same author

Unanchored by two hits: IFNγ and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo.

The British journal of dermatology·2026
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 16, 2026

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
11:13

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Published on: March 28, 2012

24.5K

Comparative Antioxidant Protection of Cochlear Hair Cells from Ototoxins.

Allen F Ryan1,2,3, Kwang Pak1, Eun Jung Lee1,4

  • 1Department of Otolaryngology, University of California San Diego, La Jolla, CA 92093, USA.

Molecules (Basel, Switzerland)
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Seratrodast and idebenone protect cochlear hair cells from damage caused by ototoxic drugs like gentamicin and cisplatin by scavenging reactive oxygen species (ROS). Their protective effects are linked to antioxidant activity, not other properties.

Keywords:
cisplatincochlear damagehair cell protectioninner ear

More Related Videos

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.9K
Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
06:07

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

3.6K

Related Experiment Videos

Last Updated: Jan 16, 2026

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
11:13

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Published on: March 28, 2012

24.5K
Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.9K
Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
06:07

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

3.6K

Area of Science:

  • Ototoxicity and neuroprotection research
  • Cellular and molecular mechanisms of hearing loss
  • Antioxidant and free radical scavenging activity

Background:

  • Cochlear hair cell (HC) damage often involves reactive oxygen species (ROS).
  • Previous screening identified limited antioxidant efficacy against gentamicin-induced HC loss.
  • Seratrodast and idebenone showed significant protection, suggesting a role beyond ROS scavenging.

Purpose of the Study:

  • To determine if the protective effects of seratrodast and idebenone against gentamicin are due to their ROS scavenging properties.
  • To investigate the protective potential of other TXA2 inhibitors and mitochondrial enhancers.
  • To assess the efficacy of seratrodast and idebenone against cisplatin-induced ototoxicity.

Main Methods:

  • In vitro screening of antioxidants for protection against gentamicin-induced HC damage.
  • Testing of TXA2 inhibitor (SQ-29548) and mitochondrial enhancer (mitochonic acid) in the same assay.
  • Evaluation of seratrodast and idebenone protection against cisplatin-induced HC damage.

Main Results:

  • Neither SQ-29548 nor mitochonic acid protected HCs from gentamicin, confirming ROS scavenging as the key mechanism for seratrodast and idebenone.
  • Seratrodast and idebenone provided protection against cisplatin-induced ototoxicity, though less effectively than against gentamicin.
  • Mitochonic acid and SQ-29548 did not protect against cisplatin-induced HC damage.

Conclusions:

  • Seratrodast and idebenone protect cochlear hair cells from gentamicin and cisplatin via free radical scavenging.
  • Protection against cisplatin is less effective, likely due to its distinct ototoxicity mechanism.
  • The findings highlight the importance of antioxidant properties in mitigating drug-induced hearing loss.