Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pore Transport and Ion-Pair Transport

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quality by Design-Based Scale-Up and Industrial Development of Turmeric Extract-Loaded Nanostructured Lipid Carriers.

Pharmaceutics·2026

Same author

Microwave-Assisted Wet Granulation for Engineering Rice Starch-Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets.

Pharmaceutics·2026

Same author

Development of Spray-Dried Mannitol-Pregelatinized Rice Starch Using SeDeM-Based Approach for Direct Compressible Cetirizine Dihydrochloride Tablets.

Pharmaceutics·2025

Same author

Synergistic co-processing of heat-moisture treated resistant rice starch with HPMC and Eudragit® S100: A novel multifunctional excipient for direct compression and colon-targeted delivery.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025

Same author

A novel directly compressible co-processed excipient, based-on rice starch for extended-release of tablets.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025

Same author

Boosting Therapeutic Effect of Turmeric, Coffee, and Chili Extracts Through Experimental Design and Encapsulation as Nanostructured Lipid Carriers for Novel Heath Supplements.

Plants (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Engineering Large Porous Mannitol-PVA Microparticles for Extended Drug Delivery via Spray Drying.

Karnkamol Trisopon¹, Ornanong Suwannapakul Kittipongpatana¹, Neungreuthai Chomchoei²

¹Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

|September 27, 2025

Summary

This study developed large porous microparticles for sustained drug delivery using spray drying. Polyvinyl alcohol (PVA) improved particle properties and controlled the release of diclofenac sodium, showing potential for inhalable dosage forms.

Keywords:

PVA diclofenac sodium extended drug delivery large porous particles mannitol spray drying

More Related Videos

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

Related Experiment Videos

Last Updated: Jul 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

Area of Science:

Pharmaceutical Technology
Materials Science
Drug Delivery Systems

Background:

Large porous particles (LPPs) are promising for drug delivery, enhancing dispersibility and controlling release.
Their porous structure, size, and shape are key factors in optimizing drug delivery performance.

Purpose of the Study:

To develop sustained-release large porous microparticles (MPDs) of mannitol, PVA, and diclofenac sodium using spray drying.
To investigate the impact of PVA concentration on particle characteristics and drug release profiles.

Main Methods:

Spray drying technique was employed to create MPDs with varying PVA concentrations (0-40%).
Particle morphology, dispersibility (Carr's Index), aerosol performance, and solid-state properties (FTIR, XRD, DSC) were analyzed.
In vitro dissolution tests were conducted to evaluate drug release kinetics.

Main Results:

PVA co-spray drying improved particle morphology, yielding spherical, non-adherent particles with good dispersibility (Carr's Index 17.56%).
MPDs exhibited characteristics suitable for inhalation (diameter >5 μm, low bulk density <0.1 g/cm³).
PVA altered mannitol's polymorphic form, and formulations showed sustained diclofenac sodium release, following Higuchi models indicative of matrix diffusion.

Conclusions:

PVA co-spray drying is effective in engineering large porous microparticles with desirable physicochemical properties.
The developed MPDs demonstrate tailored release characteristics and suitability for inhalable or controlled-release dosage forms.
This approach offers a viable strategy for advanced drug delivery system development.