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Related Experiment Video

Updated: Jan 16, 2026

Formation of Dispersible Taohong Siwu Tablets
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Oral Tablet Formulations with Lactoferrin, a Cohesive Biomacromolecule.

True L Rogers1, Andrew J Horton1, Thomas Watson1

  • 1Roquette, Midland, MI 48642, USA.

Pharmaceutics
|September 27, 2025
PubMed
Summary

Robust tablets containing bovine lactoferrin (API) were successfully developed. Various excipients and manufacturing methods, including dry granulation, yielded stable tablets with consistent performance and drug release profiles suitable for scale-up.

Keywords:
biologiccohesive APIcroscarmellosehydroxypropyl methylcelluloselactoferrinlactosemicrocrystalline celluloseoral solid dosage formproteinstability

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biotechnology

Background:

  • Bovine lactoferrin, a cohesive biomacromolecule, presents formulation challenges.
  • Understanding excipient and process impacts is crucial for tablet development.

Purpose of the Study:

  • To investigate how excipients, unit operations, and process parameters affect the processability, properties, performance, and stability of lactoferrin tablets.
  • To identify optimal formulations and manufacturing approaches for lactoferrin-containing tablets.

Main Methods:

  • Tablet formulations with lactoferrin (5-45%) were prepared using microcrystalline cellulose, croscarmellose, lactose, hydroxypropyl methylcellulose, and sodium stearyl fumarate.
  • Tablets were manufactured via direct compression or dry granulation followed by tableting.
  • Characterization included tensile strength, friability, content uniformity, and drug release performance.

Main Results:

  • Acceptable tablets were produced with lactoferrin concentrations from 15-45% using diverse excipients and methods.
  • Dry granulation improved content uniformity in some cases.
  • Excipient choice and compression force influenced drug release; lactoferrin-excipient compatibility was confirmed for up to 2 years.

Conclusions:

  • Robust, scalable tablet production is feasible for bovine lactoferrin.
  • Consistent, stable tablets with desired performance were achieved across various formulations and processing conditions.
  • Both immediate- and controlled-release profiles are attainable for lactoferrin tablets.