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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Modeling and Design of Chitosan-PCL Bi-Layered Microspheres for Intravitreal Controlled Release.

Eduardo A Chacin Ruiz1, Samantha L Carpenter2, Katelyn E Swindle-Reilly3,4,5

  • 1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Summary

Computational models can optimize bi-layered microspheres for sustained intravitreal drug delivery, improving treatment for chronic retinal diseases by reducing dosing frequency.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Computational Modeling
  • Ophthalmology

Background:

  • Chronic retinal diseases necessitate frequent local drug administration, often leading to poor patient compliance.
  • Controlled-release drug delivery systems offer an alternative to reduce intravitreal dosing frequency.
  • Developing and commercializing these systems is a lengthy process.

Purpose of the Study:

  • To model and estimate parameters for diffusion-controlled drug release from chitosan-polycaprolactone (PCL) bi-layered microspheres.
  • To optimize microsphere design for extended drug release duration.
  • To provide computational tools for designing intravitreal drug delivery systems.

Main Methods:

  • Utilized finite difference and finite element methods to solve a mathematical model for drug release.
  • Employed nonlinear least-squares regression for parameter estimation.
  • Modeled release of bovine serum albumin and bevacizumab from chitosan-PCL microspheres.

Main Results:

  • Simulated cumulative drug release under various conditions using estimated parameters.
  • Optimized device design to enhance release duration beyond the target daily therapeutic rate.
  • Investigated the impact of polymeric layer sizes on drug release kinetics.

Conclusions:

  • Identified optimal polymeric layer sizes for enhanced drug release.
  • Developed computational tools for designing bi-layered microspheres for intravitreal drug delivery.
  • Facilitated the design of improved treatments for chronic ocular neovascularization.