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Updated: Jan 16, 2026

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
Published on: August 20, 2021
Reference-guided assembly of metagenomes with MetaCompass
Tu Luan1, Victoria P Cepeda-Espinoza1, Bo Liu1
1Department of Computer Science, University of Maryland, College Park, MD 20742, USA; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.
None:
Metagenomic studies have primarily relied on de novo assembly for reconstructing genes and genomes from microbial mixtures. While reference-guided approaches have been employed in the assembly of single organisms, they have not been used in a metagenomic context. Here, we develop an effective approach for reference-guided metagenomic assembly that can complement and improve upon de novo metagenomic assembly methods for certain organisms. Such approaches will be increasingly useful as more genomes are sequenced and made publicly available.
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