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Asthma and Pregnancy: A Narrative Review.
Siara Teelucksingh1, Andrea Davis2, Catherine Nelson-Piercy3
1Department of Acute and General Internal Medicine, Guy's and St. Thomas' NHS Foundation Trust, King's College London, London, England; South West London and Surrey Heartlands Maternal Medicine Network, London, England.
Chest
|September 27, 2025
Summary
Optimizing asthma care in pregnancy is crucial. Current management strategies, including biologics, are safe and effective, improving outcomes for both mother and child.
Area of Science:
- Obstetrics and Gynecology
- Pulmonology
- Pharmacology
Background:
- Asthma affects up to 12% of pregnant women globally, posing risks for adverse perinatal outcomes if poorly controlled.
- Contemporary asthma management focuses on personalized, trait-based approaches and biomarker-directed therapies for severe cases.
- Pregnancy-related physiological changes do not typically worsen asthma severity.
Purpose of the Study:
- To review the applicability of modern asthma management principles in pregnancy.
- To update healthcare providers on evidence-based strategies for optimizing asthma care in pregnant women.
Main Methods:
- An evidence review was conducted.
- Contemporary principles of asthma management were evaluated in the context of pregnancy.
Main Results:
- Severe or poorly controlled asthma increases risks for preeclampsia, gestational diabetes, fetal growth restriction, preterm birth, and neonatal complications.
- Maternal outcomes include unplanned admissions, reduced quality of life, and psychological comorbidity.
- Most standard asthma treatments, including biologics, are safe during pregnancy and lactation, promoting adherence and improving health outcomes.
Conclusions:
- Healthcare providers should be updated on evidence-based strategies for optimizing asthma care in pregnant women.
- Proactive management, personalized treatment, and ongoing research participation are essential.
- Reassuring patients about medication safety is vital for adherence and improved maternal and fetal health.
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