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Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-IV: Diagnostic and Management01:30

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Clinical Assessment for Asthma:
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Related Experiment Video

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Association between asthma and thyroid function as well as thyroid hormone sensitivity indicators: an NHANES study.

Ke Li1, Qiangbin Ding2, Ruidong Liu3

  • 1Department of Ultrasound Medical, Zhongshan Hospital of Xiamen University, Xiamen, China.

European Journal of Medical Research
|September 27, 2025
PubMed
Summary

Thyroid hormones free triiodothyronine (FT3) and the FT3/FT4 ratio may be inversely associated with asthma risk. Lower levels of FT3 and FT3/FT4 were observed in asthmatics, but causality requires further investigation.

Keywords:
AsthmaCross-sectional studyNHANESThyroid functionThyroid hormone sensitivity indicators

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Area of Science:

  • Endocrinology
  • Pulmonology
  • Epidemiology

Background:

  • Thyroid hormones are crucial for physiological functions, including the respiratory system.
  • Emerging evidence suggests a potential link between asthma and thyroid function.
  • Limited research exists on the specific associations between asthma, thyroid hormones, and thyroid hormone sensitivity.

Purpose of the Study:

  • To investigate the relationship between asthma, thyroid function, and thyroid hormone sensitivity in U.S. adults.
  • To analyze associations using data from the National Health and Nutrition Examination Survey (NHANES).
  • To explore potential correlations between thyroid parameters and asthma risk.

Main Methods:

  • Utilized weighted analyses of NHANES 2007-2012 data (n=8160).
  • Assessed thyroid function (FT3, FT4, TSH, etc.) and sensitivity indices (FT3/FT4 ratio, TT4RI, TSHI, TFQI).
  • Conducted subgroup analyses, ROC curve investigations, and institutional validation with a retrospective cohort.

Main Results:

  • Asthmatics showed higher free triiodothyronine (FT3) and FT3/FT4 ratios but lower thyroid peroxidase antibody (TPOAb) levels.
  • Adjusted models indicated an inverse association between asthma risk and the FT3/FT4 ratio.
  • Institutional validation suggested lower FT3 levels in asthma patients, with a trend towards fewer exacerbations at higher FT3 levels.

Conclusions:

  • FT3 and FT3/FT4 levels may be inversely correlated with asthma risk.
  • The observed associations warrant further investigation due to the cross-sectional study design.
  • Causality between thyroid hormone levels and asthma remains undetermined.