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Antibiomania: A Systematic Review of Clarithromycin-Associated Manic Episodes
Tijana Marković1, Ana Todorović1, Milica Stojković1,2
1Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića.
Journal of Clinical Psychopharmacology
|September 29, 2025
Summary
Antibiotic-induced mania, known as antibiomania, can be triggered by clarithromycin. This rare side effect, characterized by mood changes and hyperactivity, typically resolves after discontinuing the antibiotic.
Area of Science:
- Pharmacovigilance
- Neuropsychiatry
- Adverse Drug Reactions
Background:
- Antibiomania is a rare adverse reaction characterized by antibiotic-induced mania.
- Clarithromycin is frequently implicated in cases of antibiomania.
- Symptoms include mood elevation, hyperactivity, and hallucinations, usually resolving post-discontinuation.
Conclusions:
- Clarithromycin can precipitate secondary mania, a rare psychiatric side effect.
- Clinician awareness is crucial for timely recognition and appropriate management.
- Prompt identification and intervention improve patient outcomes and prevent misdiagnosis.
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