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Related Experiment Video

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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial

Inga H Melvinsdottir1,2, Dan Midgett3, Shin Rong Lee4

  • 1Section of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.

Circulation. Cardiovascular Imaging
|September 29, 2025
PubMed
Summary

Intramyocardial hydrogel injection after myocardial infarction (MI) improved heart function and reduced remodeling. This treatment also promoted angiogenesis by increasing alpha-v-beta-3 (αvβ3)-integrin activation.

Keywords:
angiogenesishydrogelsmultimodal imagingmyocardial infarctiontomography, spiral computed

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Area of Science:

  • Regenerative Medicine
  • Cardiovascular Imaging
  • Biomaterials Science

Background:

  • Myocardial infarction (MI) leads to adverse left ventricular remodeling and impaired cardiac function.
  • Hydrogel injections into MI areas show potential for reducing remodeling and promoting angiogenesis.
  • Alpha-v-beta-3 (αvβ3)-integrin plays a crucial role in angiogenesis and can be targeted for therapeutic evaluation.

Purpose of the Study:

  • To assess the effects of imageable intramyocardial hydrogel delivery on left ventricular remodeling and angiogenesis post-MI using multimodality imaging.
  • To evaluate the impact of hydrogel treatment on cardiac biomechanics and functional recovery.
  • To correlate imaging findings with histological markers of angiogenesis and inflammation.

Main Methods:

  • Pigs (N=14) underwent induced MI and were randomized to receive hydrogel (n=8) or saline (n=6) injections.
  • Contrast cine-computed tomography assessed biomechanical changes pre- and post-treatment.
  • 99mTc-Maraciclatide uptake, histology (scar burden, angiogenesis, inflammation), and strain analysis were performed.

Main Results:

  • Hydrogel delivery improved left ventricular ejection fraction and reduced end-diastolic volume by day 12 post-MI.
  • Increased 99mTc-maraciclatide uptake in hydrogel-treated infarct segments indicated enhanced angiogenesis.
  • Histology confirmed increased αvβ3-integrin and factor VIII expression in the hydrogel group, without differences in scar size or inflammation.

Conclusions:

  • Early intramyocardial hydrogel delivery post-MI effectively reduces left ventricular remodeling.
  • The treatment promotes angiogenesis, evidenced by increased αvβ3-integrin activation and radiotracer uptake.
  • Multimodality imaging, including 99mTc-Maraciclatide, can evaluate therapeutic angiogenesis post-MI.