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Updated: Jan 16, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
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Docetaxel Rechallenge After Chemohormonal Therapy in High-Volume Metastatic Castration-Sensitive Prostate Cancer.

Kenichi Hata1, Yuki Takiguchi2, Yuya Iwamoto2

  • 1Department of Urology, Shonan Keiiku Hospital, Fujisawa, JPN.

Cureus
|September 29, 2025
PubMed
Summary

Docetaxel rechallenge (DR) showed limited clinical benefits in metastatic castration-resistant prostate cancer (mCRPC) patients after prior chemohormonal therapy. Further research is needed to define its role and patient selection criteria.

Keywords:
chemohormonal therapydocetaxelmetastatic castration-resistant prostate cancermetastatic castration-sensitive prostate cancerrechallenge

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