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Prolonged Length of Stay After One- and Two-Level Transforaminal Lumbar Interbody Fusion (TLIF): Risk Factors and
Mitsuhiro Nishizawa1, Steven D Glassman2, Mladen Djurasovic2
1Orthopedic Surgery, University of Louisville School of Medicine, Louisville, USA.
Cureus
|September 29, 2025
Summary
Prolonged length of stay (LOS) after spine surgery is linked to older age, longer operative time, and complications. This extended LOS is associated with increased post-discharge complications and poorer functional recovery.
Area of Science:
- Neurosurgery
- Orthopedic Surgery
- Spine Surgery
Background:
- Limited studies with granular patient data exist on factors influencing prolonged length of stay (LOS) after spine surgery.
- The association between prolonged LOS and functional recovery post-spine surgery remains under-researched.
Purpose of the Study:
- To identify factors associated with prolonged LOS following transforaminal lumbar interbody fusion (TLIF).
- To investigate the impact of prolonged LOS on postoperative complications and functional recovery.
Main Methods:
- Retrospective longitudinal observational cohort study of 576 patients undergoing one- or two-level TLIF.
- Prolonged LOS defined as >85 hours; data collected on demographics, surgical parameters, complications, and patient-reported outcome measures (PROMs).
- Multiple logistic regression used to identify factors associated with prolonged LOS and complications.
Main Results:
- Prolonged LOS was independently associated with older age, lower preoperative hemoglobin, longer operative time, and in-hospital complications.
- Patients with prolonged LOS had significantly higher rates of post-discharge complications, including readmission, surgical site infection, and DVT/PE.
- In a sub-analysis excluding post-discharge complications, prolonged LOS was linked to worse preoperative functional status (ODI, back/leg pain) and poorer postoperative recovery.
Conclusions:
- Prolonged LOS after TLIF is multifactorial, influenced by patient age, preoperative health, and surgical factors.
- Extended LOS increases the risk of both in-hospital and post-discharge complications.
- Prolonged LOS negatively impacts functional recovery, highlighting the importance of optimizing LOS for better patient outcomes.

