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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Comparative Outcomes Following Candida Bloodstream Infection in Patients With Left Ventricular Assist Devices.

Armaghan-E-Rehman Mansoor1, Gayathri Krishnan2, Julio C Zuniga-Moya2

  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, United States.

Open Forum Infectious Diseases
|September 29, 2025
PubMed
Summary

The presence of a left ventricular assist device (LVAD) did not affect 30- or 90-day mortality in patients experiencing Candida bloodstream infections (BSI). This finding holds true even after adjusting for other risk factors.

Keywords:
CandidemiaLVADLeft ventricular assist deviceMCSbloodstream infection

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Area of Science:

  • Infectious Diseases
  • Cardiology
  • Medical Devices

Background:

  • Candida bloodstream infections (BSI) are associated with severe outcomes.
  • Left ventricular assist devices (LVADs) are increasingly used for end-stage heart failure but pose infection risks.
  • This study investigates the outcomes of Candida BSI in patients with and without LVADs.

Purpose of the Study:

  • To evaluate the impact of left ventricular assist device (LVAD) presence on mortality in patients with Candida bloodstream infections (BSI).
  • To compare risk factors and outcomes between patients with Candida BSI who have an LVAD and those who do not.

Main Methods:

  • Retrospective analysis of 1233 patients with Candida BSI from 2010-2021.
  • Comparison of demographics, microbiology, and clinical factors between LVAD and non-LVAD cohorts.
  • Assessment of 30-day and 90-day mortality using adjusted Cox proportional hazards models.

Main Results:

  • Patients with LVADs were more likely male and had higher rates of central venous access and extracorporeal membrane oxygenation.
  • Candida parapsilosis was more common in the LVAD group, while Candida albicans was more prevalent in the non-LVAD group.
  • No significant difference in 30-day or 90-day all-cause mortality was observed between the LVAD and non-LVAD cohorts.

Conclusions:

  • The presence of a left ventricular assist device (LVAD) does not significantly impact 30-day or 90-day mortality in patients with Candida bloodstream infections (BSI).
  • LVADs did not emerge as an independent risk factor for increased mortality in this patient population.