Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can auditory processing dysfunction indicate early cognitive decline?

Xinrong Ma1,2,3, Jiayu Li1,2,3, Ying Wang1,2,3

  • 1Department of Otolaryngology-Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|September 29, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Field-Portable Fe(IV)-Mediated Competitive Quenching Chemiluminescence Platform with a Synchronous Y-Shaped Flow-through Cell for Broad-Spectrum Quantification of Volatile Phenols.

Analytical chemistry·2026
Same author

Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study.

Hearing research·2026
Same author

Regulating Phenolic Pollutant Polymerization from Oligomers to Multimers via Carbon Nanotubes in Permanganate Systems.

Environmental science & technology·2026
Same author

Selective degradation of tetracyclines in the Mn(II)/H<sub>2</sub>O<sub>2</sub>/HCO<sub>3</sub> process with low peroxide dosage: The neglected role of complexation-mediated electron transfer.

Journal of hazardous materials·2026
Same author

Prediction of risk of hearing loss by industry noise from cross-sectional and longitudinal data.

Communications medicine·2026
Same author

Improving the Sodium Storage Behavior of Anthracite with a Tailored Interface Layer.

Langmuir : the ACS journal of surfaces and colloids·2025
Same journal

Obstacles and solutions for implementing amyloid-targeting treatments in Europe.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Elevated sclerostin levels in cerebrospinal fluid are associated with cognitive impairment in the Alzheimer's disease continuum.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

FTLD-TDP versus LATE-NC: Experience of a Brain Bank specializing in FTLD-TDP.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Variable Aβ tracer uptake in hyperostosis frontalis interna: implications for brain Aβ PET/CT interpretation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Deep contrastive learning framework identifies cell-type-specific drug targets in Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Anti-amyloid therapy eligibility in a longitudinal brain-donor cohort with <i>post mortem</i> confirmation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
See all related articles
This summary is machine-generated.

Gap detection threshold (GDT) may indicate early cognitive impairment (CI). Higher GDT correlates with poorer cognitive function and altered brain activity, suggesting its potential as a non-invasive biomarker for dementia risk.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Cognitive Neuroscience

Background:

  • Central auditory processing (CAP) is vital for speech and cognitive functions.
  • Cognitive impairment (CI) poses a significant health challenge, with early detection being crucial.
  • Identifying reliable early markers for CI and dementia risk is a key research objective.

Purpose of the Study:

  • To investigate if gap detection threshold (GDT) can serve as an early marker for identifying individuals with cognitive impairment (CI).
  • To explore the relationship between GDT, cognitive function, and neurophysiological correlates of CI.
  • To assess the potential of GDT as a non-invasive biomarker for early detection of dementia risk.

Main Methods:

  • Sixty-four older adults participated, undergoing peripheral auditory, cognitive, and CAP assessments.
Keywords:
central auditory processingcognitive impairmentelectroencephalogramgap detection threshold

Related Experiment Videos

  • Machine learning algorithms were employed to identify predictors of CI.
  • Resting-state electroencephalography (EEG) and event-related potential (ERP) analyses were conducted to examine neural correlates.

    • Main Results:

    • Individuals with CI exhibited significantly higher GDT compared to controls (p=0.034).
    • GDT showed a significant negative correlation with cognitive test scores (e.g., ACE-III: r=-0.40, p=0.001).
    • EEG revealed altered auditory connectivity, and ERP indicated reduced N1/N2 amplitudes in high-GDT individuals (FDR corrected p < 0.05).

    Conclusions:

    • GDT may reflect early neurophysiological changes associated with cognitive impairment.
    • GDT demonstrates potential as a non-invasive biomarker for identifying individuals at high risk of dementia.
    • Auditory processing deficits, as measured by GDT, are linked to cognitive decline and altered brain function.