Lance-Adams Syndrome: An Updated Review of a Rare Post-Hypoxic Complication

This review aims to provide a comprehensive understanding of Lance-Adams Syndrome (LAS), focusing on its pathophysiology, diagnosis, management, and patient outcomes.

Utilizing the PICO framework, articles describing known cases of LAS and interventions were included, with no specific comparisons. The search was conducted in Google Scholar, PubMed, and Scopus databases.

LAS is characterized by action myoclonus and related symptoms. Imbalances in neurotransmitters and involvement of brain areas like the cerebellum, thalamus, and basal ganglia play a role in its pathophysiology. Diagnosis primarily relies on symptom history post-anoxic events, and treatments vary in effectiveness. LAS generally carries a more favorable functional prognosis than early post-anoxic status myoclonus, but often remains chronic and disabling.

LAS is a complex and rare neurological condition requiring early diagnosis and specific interventions. The compiled information provides a comprehensive overview, assisting clinicians in understanding and managing LAS. This review emphasizes the need for ongoing research and individualized patient care strategies, seeking to enhance overall patient quality of life.