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Updated: Jan 16, 2026

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
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Deaths: Leading Causes for 2023
Summary
In 2023, the leading causes of death in the U.S. saw shifts in ranking for seven of the top ten conditions. Heart disease and cancer remained the top two causes, with COVID-19 also featuring in the top ten.
Area of Science:
- Public Health
- Epidemiology
- Mortality Statistics
Background:
- Understanding leading causes of death is crucial for public health initiatives and resource allocation.
- Annual mortality data provides insights into population health trends and disease burden.
Purpose of the Study:
- To present the final 2023 data on the 10 leading causes of death in the United States.
- To detail leading causes of death by age group, race, Hispanic origin, and sex.
- To report leading causes of infant, neonatal, and postneonatal death.
Main Methods:
- Utilized death certificate data from all 50 states and the District of Columbia for 2023.
- Classified causes of death using the International Classification of Diseases, 10th Revision (ICD-10).
- Ranked causes based on the number of deaths, focusing on the underlying cause.
Main Results:
- Seven of the top 10 leading causes of death shifted in rank from 2022 to 2023.
- The top 10 causes included heart disease, malignant neoplasms, accidents, cerebrovascular diseases, chronic lower respiratory diseases, Alzheimer disease, diabetes mellitus, nephritis, chronic liver disease, and COVID-19.
- These top causes accounted for 70.9% of all deaths; leading infant causes were also detailed.
Conclusions:
- Mortality patterns in the U.S. continue to evolve, necessitating ongoing surveillance.
- The data underscores the significant impact of chronic diseases and injuries on overall mortality.
- Specific attention to infant mortality causes is vital for targeted interventions.
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