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    In 2023, the leading causes of death in the U.S. saw shifts in ranking for seven of the top ten conditions. Heart disease and cancer remained the top two causes, with COVID-19 also featuring in the top ten.

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    Area of Science:

    • Public Health
    • Epidemiology
    • Mortality Statistics

    Background:

    • Understanding leading causes of death is crucial for public health initiatives and resource allocation.
    • Annual mortality data provides insights into population health trends and disease burden.

    Purpose of the Study:

    • To present the final 2023 data on the 10 leading causes of death in the United States.
    • To detail leading causes of death by age group, race, Hispanic origin, and sex.
    • To report leading causes of infant, neonatal, and postneonatal death.

    Main Methods:

    • Utilized death certificate data from all 50 states and the District of Columbia for 2023.
    • Classified causes of death using the International Classification of Diseases, 10th Revision (ICD-10).
    • Ranked causes based on the number of deaths, focusing on the underlying cause.

    Main Results:

    • Seven of the top 10 leading causes of death shifted in rank from 2022 to 2023.
    • The top 10 causes included heart disease, malignant neoplasms, accidents, cerebrovascular diseases, chronic lower respiratory diseases, Alzheimer disease, diabetes mellitus, nephritis, chronic liver disease, and COVID-19.
    • These top causes accounted for 70.9% of all deaths; leading infant causes were also detailed.

    Conclusions:

    • Mortality patterns in the U.S. continue to evolve, necessitating ongoing surveillance.
    • The data underscores the significant impact of chronic diseases and injuries on overall mortality.
    • Specific attention to infant mortality causes is vital for targeted interventions.